Our research group is interested in how telomere-driven genomic instability contributes to carcinogenesis. For this purpose, we leverage our strength in quantitative mass spectrometry analysis to both identify novel, direct telomere-binding proteins as well as to study changes in telomeric chromatin composition upon genetic manipulation. For the latter we have established workflows for label-free quantitative proteomics analysis in combination with chromatin immunoprecipitation (qChIP-MS) and extended this work to locus-specific purification workflows. Since many telomeric proteins moonlight as transcription factors, we further study the mechanism and functional impact of their gene regulatory roles both as a feedback loop with telomeres as well as to carefully dissect separation of function.
My Mentoring Style
How would you describe your mentoring style in terms of freedom given to your students?
Selecting Research Topics?
How do you guide your PhD students in selecting research topics?
Setbacks / Challenges
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Feedback
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Consultation Frequency
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Research Group Meetings
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