Raymond Najjar
Postgraduate:
Main Appointment:
Joint Appointments:
Research Fields:
Research Areas:
Research Fields:
- STEMM – Science, Technology, Engineering, Mathematics, Medical Sciences
Research Keywords:
- Visual Neurosciences
- Light
- Myopia
- MedTech | Pupillometry | Eye Tracking
- Melanopsin
Current Appointments:
Brief Description of Research:
RESEARCH INTERESTS
Visual Neurosciences; Non-image forming responses to light; Ocular and neurological photomodulation; Light; Ophthalmology; Myopia; Artificial intelligence; MedTech.
SUMMARY
The eye is not just an extension of the brain. It’s a window to neurological health and a complex organ that drives and modulates many non-visual cerebral functions such as the pupillary light reflex, circadian entrainment, cognition, alertness, sleep, and mood. I’m interested in the neurobiological interactions between the eye and the brain and in processes by which light can regulate ocular and neurological functioning and development. My goal is to translate fundamental findings in visual neurosciences into screening and therapeutic clinical interventions.
Total Number of Publications:
Five Representative Publications:
– Milea, D*, Najjar RP*… Wong TY*, Biousse V*, for the BONSAI Group, Artificial Intelligence to Detect Papilledema from Ocular Fundus Photographs. N Engl J Med. 2020; 382:1687-1695. JIF : 176.1. * Equal contribution
https://www.nejm.org/doi/full/10.1056/NEJMoa1917130
– Najjar RP, Rukmini AV, Finkelstein MT, Nusinovici S, Mani B, Nongpiur ME, Perera S, Husain R, Aung T, Milea D. Handheld chromatic pupillometry can accurately and rapidly reveal functional loss in glaucoma. Br J Ophthalmol 2021; bjophthalmol-2021-319938. doi:10.1136/bjophthalmol-2021-319938 JIF: 6.0
https://bjo.bmj.com/content/107/5/663
– Muralidharan AR, Low SWY, Lee YC, Barathi VA, Saw SM, Milea D, Najjar RP. Recovery from Form-Deprivation Myopia in Chicks Is Dependent Upon the Fullness and Correlated Color Temperature of the Light Spectrum. Invest Ophthalmol Vis Sci. 2022 Feb 1;63(2):16. JIF: 4.9
https://doi.org/10.1167/iovs.63.2.16
– Najjar RP, Sharma S, Atalay E, Rukmini AV, Sun C, Lock J-Z, Baskaran M, Perera SA, Husain R, Gooley JJ, Lamoureux E, Aung T, Milea D. Pupillary responses to full-field chromatic stimuli are reduced in patients with early-stage primary open-angle glaucoma. Ophthalmology. 2018; 125(9):1362-71. JIF: 12.1
https://doi.org/10.1016/j.ophtha.2018.02.024
– Najjar RP and Zeitzer JM. Temporal integration of light flashes by the human circadian system (Clinical Trial). J Clin Invest. Feb 2016;126(3):938-47. JIF: 13.2
https://www.jci.org/articles/view/82306
My Research Videos:
Top 5 Publications:
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Journals Published:
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Appointments
Education
Research Areas
- Visual Neurosciences
- Light
- Myopia
- MedTech | Pupillometry | Eye Tracking
- Melanopsin
Research Description
RESEARCH INTERESTS
Visual Neurosciences; Non-image forming responses to light; Ocular and neurological photomodulation; Light; Ophthalmology; Myopia; Artificial intelligence; MedTech.
SUMMARY
The eye is not just an extension of the brain. It’s a window to neurological health and a complex organ that drives and modulates many non-visual cerebral functions such as the pupillary light reflex, circadian entrainment, cognition, alertness, sleep, and mood. I’m interested in the neurobiological interactions between the eye and the brain and in processes by which light can regulate ocular and neurological functioning and development. My goal is to translate fundamental findings in visual neurosciences into screening and therapeutic clinical interventions.
Research Videos
Selected Publications
– Milea, D*, Najjar RP*… Wong TY*, Biousse V*, for the BONSAI Group, Artificial Intelligence to Detect Papilledema from Ocular Fundus Photographs. N Engl J Med. 2020; 382:1687-1695. JIF : 176.1. * Equal contribution
https://www.nejm.org/doi/full/10.1056/NEJMoa1917130
– Najjar RP, Rukmini AV, Finkelstein MT, Nusinovici S, Mani B, Nongpiur ME, Perera S, Husain R, Aung T, Milea D. Handheld chromatic pupillometry can accurately and rapidly reveal functional loss in glaucoma. Br J Ophthalmol 2021; bjophthalmol-2021-319938. doi:10.1136/bjophthalmol-2021-319938 JIF: 6.0
https://bjo.bmj.com/content/107/5/663
– Muralidharan AR, Low SWY, Lee YC, Barathi VA, Saw SM, Milea D, Najjar RP. Recovery from Form-Deprivation Myopia in Chicks Is Dependent Upon the Fullness and Correlated Color Temperature of the Light Spectrum. Invest Ophthalmol Vis Sci. 2022 Feb 1;63(2):16. JIF: 4.9
https://doi.org/10.1167/iovs.63.2.16
– Najjar RP, Sharma S, Atalay E, Rukmini AV, Sun C, Lock J-Z, Baskaran M, Perera SA, Husain R, Gooley JJ, Lamoureux E, Aung T, Milea D. Pupillary responses to full-field chromatic stimuli are reduced in patients with early-stage primary open-angle glaucoma. Ophthalmology. 2018; 125(9):1362-71. JIF: 12.1
https://doi.org/10.1016/j.ophtha.2018.02.024
– Najjar RP and Zeitzer JM. Temporal integration of light flashes by the human circadian system (Clinical Trial). J Clin Invest. Feb 2016;126(3):938-47. JIF: 13.2
https://www.jci.org/articles/view/82306