Makkar, Hardik

Hardik Makkar

Nationality: India
Faculty & Year of Study: Faculty of Dentistry, Year 2
Undergraduate: JSS Academy of Higher Education and Research, India

"Break stereotypes; Stay Curious & Chase Your Passion, Not Pension!"

Why did you choose to pursue a PhD?

      As a curious teenager, I remember being fascinated with the world under the microscope. Visualizing how cells divide and differentiate made me realize that even a singular life form can be so intricately complex. The biology classes at school were intriguing enough to motivate and shape my naive mind to delve further into the subject of life sciences.
     Almost two decades later, with academic and professional experience in the field of oral health sciences, I believe there were three primary learnings that led a clinically trained dentist like me to venture into an exciting track of research and innovation.
     The first learning was realizing the importance of academic and research rigor on the path to attain professional excellence. The second learning centered around the importance of interdisciplinary teamwork. Finally, my third learning was the realization that the end goal of research should lie in its ability to impact lives positively.
     Despite my previous professional roles and engagements, I soon came to realize my academic limitations, especially in a thorough understanding of concepts and techniques in basic research. My determination to contribute meaningfully in the field for a larger cause cannot be achieved without an advanced research degree. Via a careful examination of my abilities and passion to bring about a change, I aspire to fill these lacunae by gaining knowledge, experience, and mentorship through my PhD here at NUS.

Why Did You Choose To Pursue Your PhD At NUS?

     I believe that a Ph.D. at the Faculty of Dentistry, NationalUniversity of Singapore complements my research interests and provides a stimulating and challenging environment to facilitate my learning. The department has its strength and high research output in the domain of Craniofacial Tissue engineering for understanding oral diseases. This converges with my academic background and future research goals.
   NUS has a holistic growth environment that supports my research aspirations through its dedicated and cutting edge research facilities. The synergistic collaboration of faculties with clinical departments, consortium of internationally renowned researchers at national health and research agencies is an added advantage to enhance my research and its impact. This interdisciplinary exposure via the PhD program here is immensely enriching, both culturally and academically. I am very grateful to be a part of it.

Can you tell us briefly about your research topic?

    My research is centered around developing and validating preclinical models to understand oral host-microbe interaction. Oral bacteria contribute towards the health and physiological state of the oral cavity and any disruption and imbalance in this equilibrium contribute towards one of the most chronic prevalent diseases,Periodontitis.
     Our lab is working towards developing disease models using complex organotypic cultures grown on dishes as well as microfluidic organ-on-chip platform. These models recapitulate the way a tissue or part of the organ/ecosystem works in a near-physiological and pathological microenvironment. Our lab believes that these novel models will offer advantages in the form of replacement or reduction on the use of animals in research and provide greater insights in understand the pathophysiology of infective oral diseases.

Any other words of wisdom to share?

Break stereotypes
Stay Curious &
Chase your passion, not pension!