phclowcm@nus.edu.sg

Chian Ming Low

Singapore
Associate Professor

Postgraduate:

King’s College London
Singapore

Main Appointment:

Medicine (Pharmacology)

Joint Appointments:

Research Fields:

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Research Areas:

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Research Fields:

  • STEMM – Science, Technology, Engineering, Mathematics, Medical Sciences

Research Keywords:

  • Neuropharmacology
  • Chronic Pain
  • Personalized Medicine
  • Brain Connectomics

Current Appointments:

1. Deputy Head, Department of Pharmacology
2. Associate Professor, Department of Anaesthesia (conjoint)
3. Deputy Director (Research Policy & Administration), Deputy President (Research & Technology) Office
4. Deputy Director (Research Compliance & Integrity), Deputy President (Research & Technology) Office
5. Deputy Chair, Institutional Animal Care & Use Committee, Deputy President (Research & Technology) Office

Brief Description of Research:

My research team probes the fundamental brain changes at cellular level to understand behavioural changes using animal models with an aim on drug discovery leading towards personalized medicine. A more global approach is on brain network mapping which can have a broad impact across disciplines ranging from medicine to computing.

Total Number of Publications:

Five Representative Publications:

Chin, A-L. , Yang, S-M., Chen, Li, M-T., T-T., Chen, Y-J., Lee. T-K., Petibois, C., Cai X., Low, C-M., Tan, F.C.K., Teo, A., Tok, E.S., Ong, E.B.L., Lin, Y-Y., Lin, I-J., Tseng, Y-C., Chen, N-Y., Shih, C-T., Lim, J-H., Je, J-H, Kohmura, Y., Ishikawa, T., Margaritondo, G., Chiang, A-S. * and Hwu, Y.* (2020). A synchrotron X-ray imaging strategy to map large animal brains. Ch. J. Phys. 65:24-32 doi.org/10.1016/j.cjph.2020.01.010

Ng, C.Y., Kannan, S., Chen, Y.J., Tan, F.C.K, Ong, W.Y., Go, M.L., Verma, C.S.*, Low, C-M.* and Lam, Y.* (2017). A new generation of arachidonic acid analogues as potential neurological agent targeting cytosolic phospholipase A2. Sci. Rep. 7:13683.

Ng, C.Y., Kwok, T.X.W., Tan, F.C.K., Low, C-M* and Lam, Y*. Fluorogenic probes to monitor cytosolic phospholipase A2 activity. Chem. Comms. 53:1813-1816

Perszyk, R.E., DiRaddo, J.O., Strong, K.L., Low, C-M., Ogden, K.K., Khatri A., Vargish, G.A., Pelkey, K.A., Tricoire, L., Liotta, D.C., Smith, Y., McBain, C.J. and Traynelis, S.F.* (2016). GluN2D-containing NMDA receptors mediate synaptic transmission in hippocampal interneurons. Mol. Pharmacol. 90:689-702

Ariffin, M.Z., Low, C-M., Khanna, S.* (2017). Medial septum modulates cellular responses induced in hippocampus on microinjection of cholinergic agonists into hypothalamic supramammillary nucleus. Front Neuroanat. 11:79

My Research Videos:

Top 5 Publications:

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Journals Published:

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Chian Ming Low

Associate Professor
Medicine (Pharmacology)
Singapore
phclowcm@nus.edu.sg

Appointments

1. Deputy Head, Department of Pharmacology
2. Associate Professor, Department of Anaesthesia (conjoint)
3. Deputy Director (Research Policy & Administration), Deputy President (Research & Technology) Office
4. Deputy Director (Research Compliance & Integrity), Deputy President (Research & Technology) Office
5. Deputy Chair, Institutional Animal Care & Use Committee, Deputy President (Research & Technology) Office

Education

King’s College London
Singapore

Research Areas

  • Neuropharmacology
  • Chronic Pain
  • Personalized Medicine
  • Brain Connectomics

Research Description

My research team probes the fundamental brain changes at cellular level to understand behavioural changes using animal models with an aim on drug discovery leading towards personalized medicine. A more global approach is on brain network mapping which can have a broad impact across disciplines ranging from medicine to computing.

Research Videos

Selected Publications

(out of publications)

Chin, A-L. , Yang, S-M., Chen, Li, M-T., T-T., Chen, Y-J., Lee. T-K., Petibois, C., Cai X., Low, C-M., Tan, F.C.K., Teo, A., Tok, E.S., Ong, E.B.L., Lin, Y-Y., Lin, I-J., Tseng, Y-C., Chen, N-Y., Shih, C-T., Lim, J-H., Je, J-H, Kohmura, Y., Ishikawa, T., Margaritondo, G., Chiang, A-S. * and Hwu, Y.* (2020). A synchrotron X-ray imaging strategy to map large animal brains. Ch. J. Phys. 65:24-32 doi.org/10.1016/j.cjph.2020.01.010

Ng, C.Y., Kannan, S., Chen, Y.J., Tan, F.C.K, Ong, W.Y., Go, M.L., Verma, C.S.*, Low, C-M.* and Lam, Y.* (2017). A new generation of arachidonic acid analogues as potential neurological agent targeting cytosolic phospholipase A2. Sci. Rep. 7:13683.

Ng, C.Y., Kwok, T.X.W., Tan, F.C.K., Low, C-M* and Lam, Y*. Fluorogenic probes to monitor cytosolic phospholipase A2 activity. Chem. Comms. 53:1813-1816

Perszyk, R.E., DiRaddo, J.O., Strong, K.L., Low, C-M., Ogden, K.K., Khatri A., Vargish, G.A., Pelkey, K.A., Tricoire, L., Liotta, D.C., Smith, Y., McBain, C.J. and Traynelis, S.F.* (2016). GluN2D-containing NMDA receptors mediate synaptic transmission in hippocampal interneurons. Mol. Pharmacol. 90:689-702

Ariffin, M.Z., Low, C-M., Khanna, S.* (2017). Medial septum modulates cellular responses induced in hippocampus on microinjection of cholinergic agonists into hypothalamic supramammillary nucleus. Front Neuroanat. 11:79