As a Clinician-Scientist and Singapore Translational Research Award Investigator, my area of dementia research, of particular importantance to Singapore and Asia, is Vascular and Neurodegenerative Mechanisms in Dementia. Vascular disease is prominent among ethnic Asian dementia patients. Compared to Caucasian populations, a higher prevalence of Vascular Dementia has been reported in Asian countries such as Japan and China. Moreover, studies have revealed a vascular basis contributing to the etiology and pathogenesis of Alzheimer's Disease. The identification of biomarkers for vascular and neurodegenerative mechanisms, and insights into the mechanisms of interaction may lead to potential therapeutic approaches.

This will not only give rise to novel scientific insights and advances but also be of immense potential benefit to Singaporeans and the biomedical industry since the increasing numbers of patients suffering from dementia exact a massive toll in health care costs, disability and lost productivity for both patients and caregivers.

Core Research Projects:

1) Neurochemistry, Molecular Pathology and Biomarker Discovery
2) Dementia Neuroimaging using Multi-Modal Magnetic Resonance and Retinal Imaging
3) Artificial Intelligence applied to Biomarker Research
4) Epidemiology of Dementia in Singapore: Ethnicity and Risk Factors
5) Clinical Trials for Cognitive Impairment and Dementia