Chew-Kiat Heng
Postgraduate:
Main Appointment:
Joint Appointments:
Research Fields:
Research Areas:
Research Fields:
- STEMM – Science, Technology, Engineering, Mathematics, Medical Sciences
Research Keywords:
- Cardiovascular
- Coronary Artery Disease
- Genomics
- Heart
- Novel Protein
Current Appointments:
Brief Description of Research:
Coronary artery disease (CAD) is one of the the top killers in developed nations and in Singapore. It is a complex disease with genetic and environmental risk factors contributing to its etiology. There are several ongoing projects being conducted in our Cardiovascular Genomics Lab. Some of these examine the contribution of specific genes that confer susceptibility to CAD. Of interest is also patients who suffer a heart attack at a very young age (<40 years). The methodologies involve in these studies include genome-wide association study (GWAS), next-generation sequencing, gene expression profiling and other standard molecular genetics techniques such as DNA extraction, real-time PCR, genotyping and DNA sequencing. There is also a study that characterize a novel protein that plays a role in CAD. The common objectives of these projects are to determine and understand the contributing genetic factors to CAD and to develop methods to better predict the disease risk.
Total Number of Publications:
Five Representative Publications:
1. Ooi DSQ, Ong SM, Eng MH, Chan YH, Lee YS, Low AFH, Chan MY, Heng CK (2020) Detection of ADTRP in circulation and its role as a novel biomarker for coronary artery disease. PLoS ONE 15(8): e0237074. https://doi.org/10.1371/journal.pone.0237074
2. Dorajoo R, Chang X, Gurung RL, Li Z, Wang L, Wang R, Beckman KB, Adams-Haduch J, M Y, Liu S, Meah WY, Sim KS, Lim SC, Friedlander Y, Liu J, van Dam RM, Yuan JM, Koh WP, Khor CC, Heng CK (2019) Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies. Nat Commun.10:2491.
3. Bentley AR et al (2019) Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nat Genet 51:636-648.
4. Chang X, Dorajoo R, Sun Y, Han Y, Wang L, Khor CC, Sim X, Tai ES, Liu J, Yuan JM, Koh WP, van Dam RM, Friedlander Y, Heng CK (2018) Gene-diet interaction effects on BMI levels in the Singapore Chinese population. 106. Nutr J. 24;17:31.
5. Han Y, Dorajoo R, Chang X, Wang L, Khor CC, Sim X, Cheng CY, Shi Y, Tham YC, Zhao W, Chee ML, Sabanayagam C, Chee ML, Tan N, Wong TY, Tai ES, Liu J, Goh DYT, Yuan JM, Koh WP, van Dam RM, Low AF, Chan MY, Friedlander Y, Heng CK (2017). Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia. Sci Rep. 7:17921.
My Research Videos:
Top 5 Publications:
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Journals Published:
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Appointments
Education
Research Areas
- Cardiovascular
- Coronary Artery Disease
- Genomics
- Heart
- Novel Protein
Research Description
Coronary artery disease (CAD) is one of the the top killers in developed nations and in Singapore. It is a complex disease with genetic and environmental risk factors contributing to its etiology. There are several ongoing projects being conducted in our Cardiovascular Genomics Lab. Some of these examine the contribution of specific genes that confer susceptibility to CAD. Of interest is also patients who suffer a heart attack at a very young age (<40 years). The methodologies involve in these studies include genome-wide association study (GWAS), next-generation sequencing, gene expression profiling and other standard molecular genetics techniques such as DNA extraction, real-time PCR, genotyping and DNA sequencing. There is also a study that characterize a novel protein that plays a role in CAD. The common objectives of these projects are to determine and understand the contributing genetic factors to CAD and to develop methods to better predict the disease risk.
Research Videos
Selected Publications
1. Ooi DSQ, Ong SM, Eng MH, Chan YH, Lee YS, Low AFH, Chan MY, Heng CK (2020) Detection of ADTRP in circulation and its role as a novel biomarker for coronary artery disease. PLoS ONE 15(8): e0237074. https://doi.org/10.1371/journal.pone.0237074
2. Dorajoo R, Chang X, Gurung RL, Li Z, Wang L, Wang R, Beckman KB, Adams-Haduch J, M Y, Liu S, Meah WY, Sim KS, Lim SC, Friedlander Y, Liu J, van Dam RM, Yuan JM, Koh WP, Khor CC, Heng CK (2019) Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies. Nat Commun.10:2491.
3. Bentley AR et al (2019) Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nat Genet 51:636-648.
4. Chang X, Dorajoo R, Sun Y, Han Y, Wang L, Khor CC, Sim X, Tai ES, Liu J, Yuan JM, Koh WP, van Dam RM, Friedlander Y, Heng CK (2018) Gene-diet interaction effects on BMI levels in the Singapore Chinese population. 106. Nutr J. 24;17:31.
5. Han Y, Dorajoo R, Chang X, Wang L, Khor CC, Sim X, Cheng CY, Shi Y, Tham YC, Zhao W, Chee ML, Sabanayagam C, Chee ML, Tan N, Wong TY, Tai ES, Liu J, Goh DYT, Yuan JM, Koh WP, van Dam RM, Low AF, Chan MY, Friedlander Y, Heng CK (2017). Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia. Sci Rep. 7:17921.