Shiao-yng Chan
Postgraduate:
Main Appointment:
Joint Appointments:
Research Fields:
Research Areas:
Research Fields:
- STEMM – Science, Technology, Engineering, Mathematics, Medical Sciences
Research Keywords:
- Pregnancy
- Placenta
- Diabetes
- Lipidomics
- Preterm Birth
Current Appointments:
Brief Description of Research:
As a Clinician Scientist and practicing Obstetrician, my research covers the spectrum from basic laboratory science to translational sciences and clinical trials during preconception and pregnancy. The main focus is understanding the normal physiological development and the pathophysiological impact of different environmental and maternal medical conditions on the placenta and fetus in utero, and the offspring during childhood.
Total Number of Publications:
Five Representative Publications:
1. Current approaches and developments in transcript profiling of the human placenta.
Yong HEJ and Chan SY. (2020) Human Reproduction Update. In press
2. High placental inositol content associated with suppressed pro-adipogenic effects of maternal glycaemia in offspring: the GUSTO cohort.
Chu AHY, Tint M, Chang HF, Wong G, Yuan WL, Tull D, Nijagal B, Narayana V, Meikle P, Chang KTE, Lewis R, Chi C, Yap F, Tan KH, Shek L, Chong YS, Gluckman P, Lee YS, Fortier M, Godfrey K, Eriksson J, Karnani N, Chan S-Y. (2020) International Journal of Obesity (in press), https://doi.org/10.1038/s41366-020-0596-5
3. Myo-inositol alters 13C-labeled fatty acid metabolism in human placental explants.
Watkins OC, Islam MO, Selvam P, Pillai RA, Cazenave-Gassiot A, Bendt AK, Karnani N, Godfrey KM, Lewis RM, Wenk MR, Chan SY. (2019) Journal of Endocrinology 234(1):73-84, https://doi.org/10.1530/JOE-19-0267
4. Triiodothyronine regulates angiogenic growth factor and cytokine secretion by isolated human decidual cells in a cell-type specific and gestational age-dependent manner.
Vasilopoulou E, Loubière LS, Lash GE, Ohizua O, McCabe CJ, Franklyn JA, Kilby MD, Chan SY. (2014) Human Reproduction 29(6):1161-72. https://doi.org/10.1093/humrep/deu046
5. Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception.
Dhillon-Smith RK, Middleton LJ, Sunner KK, Cheed V, Baker K, Farrell-Carver S, Bender-Atik R, Agrawal R, Bhatia K, Edi-Osagie E, Ghobara T, Gupta P, Jurkovic D, Khalaf Y, MacLean M, McCabe C, Mulbagal K, Nunes N, Overton C, Quenby S, Rai R, Raine-Fenning N, Robinson L, Ross J, Sizer A, Small R, Tan A, Underwood M, Kilby MD, Boelaert K, Daniels J, Thangaratinam S, Chan SY, Coomarasamy A. (2019) New England Journal of Medicine 380(14):1316-1325. https://doi.org/10.1056/NEJMoa1812537.
My Research Videos:
Top 5 Publications:
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Journals Published:
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Shiao-yng Chan
Appointments
Education
Research Areas
- Pregnancy
- Placenta
- Diabetes
- Lipidomics
- Preterm Birth
Research Description
As a Clinician Scientist and practicing Obstetrician, my research covers the spectrum from basic laboratory science to translational sciences and clinical trials during preconception and pregnancy. The main focus is understanding the normal physiological development and the pathophysiological impact of different environmental and maternal medical conditions on the placenta and fetus in utero, and the offspring during childhood.
Research Videos
Selected Publications
1. Current approaches and developments in transcript profiling of the human placenta.
Yong HEJ and Chan SY. (2020) Human Reproduction Update. In press
2. High placental inositol content associated with suppressed pro-adipogenic effects of maternal glycaemia in offspring: the GUSTO cohort.
Chu AHY, Tint M, Chang HF, Wong G, Yuan WL, Tull D, Nijagal B, Narayana V, Meikle P, Chang KTE, Lewis R, Chi C, Yap F, Tan KH, Shek L, Chong YS, Gluckman P, Lee YS, Fortier M, Godfrey K, Eriksson J, Karnani N, Chan S-Y. (2020) International Journal of Obesity (in press), https://doi.org/10.1038/s41366-020-0596-5
3. Myo-inositol alters 13C-labeled fatty acid metabolism in human placental explants.
Watkins OC, Islam MO, Selvam P, Pillai RA, Cazenave-Gassiot A, Bendt AK, Karnani N, Godfrey KM, Lewis RM, Wenk MR, Chan SY. (2019) Journal of Endocrinology 234(1):73-84, https://doi.org/10.1530/JOE-19-0267
4. Triiodothyronine regulates angiogenic growth factor and cytokine secretion by isolated human decidual cells in a cell-type specific and gestational age-dependent manner.
Vasilopoulou E, Loubière LS, Lash GE, Ohizua O, McCabe CJ, Franklyn JA, Kilby MD, Chan SY. (2014) Human Reproduction 29(6):1161-72. https://doi.org/10.1093/humrep/deu046
5. Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception.
Dhillon-Smith RK, Middleton LJ, Sunner KK, Cheed V, Baker K, Farrell-Carver S, Bender-Atik R, Agrawal R, Bhatia K, Edi-Osagie E, Ghobara T, Gupta P, Jurkovic D, Khalaf Y, MacLean M, McCabe C, Mulbagal K, Nunes N, Overton C, Quenby S, Rai R, Raine-Fenning N, Robinson L, Ross J, Sizer A, Small R, Tan A, Underwood M, Kilby MD, Boelaert K, Daniels J, Thangaratinam S, Chan SY, Coomarasamy A. (2019) New England Journal of Medicine 380(14):1316-1325. https://doi.org/10.1056/NEJMoa1812537.