Chwee Teck Lim

Professor

Postgraduate:

University of Cambridge
United Kingdom

Main Appointment:

College of Design and Engineering (Biomedical Engineering)

Joint Appointments:

Joint Appointments:
  • Mechanolobiology Institute
  • Institute For Health Innovation & Technology
  • Singapore-MIT Alliance for Research and Technology Centre
  • Research Fields:

    [supervisor_research_field]

    Research Areas:

    [supervisor_research_area]

    Research Fields:

    • STEMM – Science, Technology, Engineering, Mathematics, Medical Sciences

    Research Keywords:

    • Biomedical Technology
    • Mechanobiology
    • Microfluidics
    • Soft Wearable Technology
    • Cancer, Infectious Diseases. Diabetes

    Current Appointments:

    Director, Institute for Health Innovation and Technology
    Principal Investigator, Mechanobiology Institute
    Founding Director, Singapore Health Technologies Consortium

    Brief Description of Research:

    We aim to address important scientific and biomedical problems using interdisciplinary approaches, develop innovative solutions and translate them for biological and healthcare applications. Our focused areas include mechanobiology of human diseases such as cancer and malaria, and the development of microfluidic technologies and soft wearable devices for human disease diagnosis and precision therapy.

    Another major research interest is collective cell migration which is central to the development and maintenance of multicellular organisms and requires orchestrated movement of cells in specific directions to specific locations and within geometrical constraints. Thus, understanding the mechanisms by which cells collective migrate may potentially lead to the development of therapeutic strategies for diseases such as cancer or for tissue repair. Here, we seek to understand how mechanical factors and cues such as substrate stiffness and confined space can regulate and coordinate collective migration of cells as well as force transmission across the cell sheet.

    Total Number of Publications:

    427

    Five Representative Publications:

    1. Jain, S et al., Emergence of single cell mechanical behavior and polarity within epithelial monolayers drives collective cell migration, Nature Physics, 16, 802–809, 2020.
    2. S B Lim et al., Addressing Cellular Heterogeneity in Tumor and Circulation for Refined Prognostication, Proceedings of the National Academy of Sciences, 116, 17957–17962, 2019.
    3. T B Saw et al., Topological Defects in Epithelia Govern Cell Death and Extrusion, Nature, 544, 212–216, 2017.
    4. S B Lim et al., An Extracellular Matrix-Related Prognostic and Predictive Indicator for Early-Stage Non-Small Cell Lung Cancer, Nature Communications, 8, 1734, 2017.
    5. Khoo, B L et al., Liquid Biopsy and Therapeutic Response: Circulating Tumor Cell Cultures for Evaluation of Anti-Cancer Treatment, Science Advances, 2, 7, e1600274, 2016.

    My Research Videos:

    Top 5 Publications:

    • Lorem ipsum dolor sit amet
    • Lorem ipsum dolor sit amet
    • Lorem ipsum dolor sit amet
    • Lorem ipsum dolor sit amet
    • Lorem ipsum dolor sit amet

    Journals Published:

    • Lorem ipsum dolor sit amet
    • Lorem ipsum dolor sit amet
    • Lorem ipsum dolor sit amet
    • Lorem ipsum dolor sit amet
    • Lorem ipsum dolor sit amet

    Chwee Teck Lim

    Professor
    College of Design and Engineering (Biomedical Engineering)
    Mechanolobiology Institute
    Institute For Health Innovation & Technology
    Singapore-MIT Alliance for Research and Technology Centre

    Appointments

    Director, Institute for Health Innovation and Technology
    Principal Investigator, Mechanobiology Institute
    Founding Director, Singapore Health Technologies Consortium

    Education

    University of Cambridge
    United Kingdom

    Research Areas

    • Biomedical Technology
    • Mechanobiology
    • Microfluidics
    • Soft Wearable Technology
    • Cancer, Infectious Diseases. Diabetes

    Research Description

    We aim to address important scientific and biomedical problems using interdisciplinary approaches, develop innovative solutions and translate them for biological and healthcare applications. Our focused areas include mechanobiology of human diseases such as cancer and malaria, and the development of microfluidic technologies and soft wearable devices for human disease diagnosis and precision therapy.

    Another major research interest is collective cell migration which is central to the development and maintenance of multicellular organisms and requires orchestrated movement of cells in specific directions to specific locations and within geometrical constraints. Thus, understanding the mechanisms by which cells collective migrate may potentially lead to the development of therapeutic strategies for diseases such as cancer or for tissue repair. Here, we seek to understand how mechanical factors and cues such as substrate stiffness and confined space can regulate and coordinate collective migration of cells as well as force transmission across the cell sheet.

    Research Videos

    Selected Publications

    (out of 427 publications)

    1. Jain, S et al., Emergence of single cell mechanical behavior and polarity within epithelial monolayers drives collective cell migration, Nature Physics, 16, 802–809, 2020.
    2. S B Lim et al., Addressing Cellular Heterogeneity in Tumor and Circulation for Refined Prognostication, Proceedings of the National Academy of Sciences, 116, 17957–17962, 2019.
    3. T B Saw et al., Topological Defects in Epithelia Govern Cell Death and Extrusion, Nature, 544, 212–216, 2017.
    4. S B Lim et al., An Extracellular Matrix-Related Prognostic and Predictive Indicator for Early-Stage Non-Small Cell Lung Cancer, Nature Communications, 8, 1734, 2017.
    5. Khoo, B L et al., Liquid Biopsy and Therapeutic Response: Circulating Tumor Cell Cultures for Evaluation of Anti-Cancer Treatment, Science Advances, 2, 7, e1600274, 2016.