Shyong Wei, Kevin Tan
Postgraduate:
Main Appointment:
Joint Appointments:
Research Fields:
Research Areas:
Research Fields:
- STEMM – Science, Technology, Engineering, Mathematics, Medical Sciences
Research Keywords:
- Malaria
- Cell Death
- Blastocystis
- Microbiome
- Bioimaging
Current Appointments:
Brief Description of Research:
Kevin SW TAN is Associate Professor at and Head of the Department of Microbiology and Immunology, National University of Singapore. He is also Vice-Dean, Graduate Studies, at the Yong Loo Lin School of Medicine and Head, Innovation in Graduate Studies, at the National University Health System. His curiosity for parasites originated from his graduate student days at NUS and blossomed during his postdoctoral stint at The Rockefeller University, New York City. He is relieved to be awarded tenure in 2011, and can now spend more time on social issues, such as public science education. Kevin’s research focuses on understanding how parasites commit suicide and exploiting such knowledge to trigger death mechanisms as an anti-parasite strategy. He is also interested in the problem of drug resistance and his team has recently come up with new ways to find drugs that overcome resistance. More recently, his team has embarked on projects focusing on the role of single cell eukaryotes (SCEs) in the host microbiome. He hopes that the research from his team would accelerate the finding of new cures for parasitic diseases.
Total Number of Publications:
Five Representative Publications:
1. Yason JA, Liang YR, Png CW, Zhang YL, Tan KSW (2019) Interactions between a pathogenic Blastocystis subtype and gut microbiota: in vitro and in vivo studies. Microbiome 7:30.
2. Li FJ, Tsaousis AD, Purton P, Chow VTK, He CY, Tan KSW (2019) Successful genetic transfection of the colonic parasite Blastocystis for reliable expression of ectopic genes. Sci. Rep. 9, 3159.
3. Tong JX, Ang SEL, Tan EHN, Tan KSW (2019) Viability screen of LOPAC1280 reveals tyrosine kinase inhibitor tyrphostin A9 as a novel partner drug for artesunate combinations to target the Plasmodium falciparum ring stage. Antimicrob. Agents Chemother. 63(4):e02389-18.
4. Yason JA, Ajjampur SS, Tan KSW (2016) Blastocystis isolate B exhibits multiple modes of resistance against antimicrobial peptide LL-37. Infect. Immun. 84(8):2220-2232.
5. Wang JG, Zhang CJ, Chia WN, Loh CCY, Li ZJ, Lee YM, He YK, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang JB, Lu NC, Lim CT, Hua ZC, Liu B, Shen HM, Tan KSW,* Lin QS* (2015) Heme-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat. Commun. 6:10111 (* co-corresponding authors)
My Research Videos:
Top 5 Publications:
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Journals Published:
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Appointments
Education
Research Areas
- Malaria
- Cell Death
- Blastocystis
- Microbiome
- Bioimaging
Research Description
Kevin SW TAN is Associate Professor at and Head of the Department of Microbiology and Immunology, National University of Singapore. He is also Vice-Dean, Graduate Studies, at the Yong Loo Lin School of Medicine and Head, Innovation in Graduate Studies, at the National University Health System. His curiosity for parasites originated from his graduate student days at NUS and blossomed during his postdoctoral stint at The Rockefeller University, New York City. He is relieved to be awarded tenure in 2011, and can now spend more time on social issues, such as public science education. Kevin’s research focuses on understanding how parasites commit suicide and exploiting such knowledge to trigger death mechanisms as an anti-parasite strategy. He is also interested in the problem of drug resistance and his team has recently come up with new ways to find drugs that overcome resistance. More recently, his team has embarked on projects focusing on the role of single cell eukaryotes (SCEs) in the host microbiome. He hopes that the research from his team would accelerate the finding of new cures for parasitic diseases.
Research Videos
Selected Publications
1. Yason JA, Liang YR, Png CW, Zhang YL, Tan KSW (2019) Interactions between a pathogenic Blastocystis subtype and gut microbiota: in vitro and in vivo studies. Microbiome 7:30.
2. Li FJ, Tsaousis AD, Purton P, Chow VTK, He CY, Tan KSW (2019) Successful genetic transfection of the colonic parasite Blastocystis for reliable expression of ectopic genes. Sci. Rep. 9, 3159.
3. Tong JX, Ang SEL, Tan EHN, Tan KSW (2019) Viability screen of LOPAC1280 reveals tyrosine kinase inhibitor tyrphostin A9 as a novel partner drug for artesunate combinations to target the Plasmodium falciparum ring stage. Antimicrob. Agents Chemother. 63(4):e02389-18.
4. Yason JA, Ajjampur SS, Tan KSW (2016) Blastocystis isolate B exhibits multiple modes of resistance against antimicrobial peptide LL-37. Infect. Immun. 84(8):2220-2232.
5. Wang JG, Zhang CJ, Chia WN, Loh CCY, Li ZJ, Lee YM, He YK, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang JB, Lu NC, Lim CT, Hua ZC, Liu B, Shen HM, Tan KSW,* Lin QS* (2015) Heme-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat. Commun. 6:10111 (* co-corresponding authors)