Shyong Wei, Kevin Tan

Singapore
Associate Professor

Postgraduate:

National University of Singapore
Singapore

Main Appointment:

Medicine (Microbiology & Immunology)

Joint Appointments:

Research Fields:

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Research Areas:

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Research Fields:

  • STEMM – Science, Technology, Engineering, Mathematics, Medical Sciences

Research Keywords:

  • Malaria
  • Cell Death
  • Blastocystis
  • Microbiome
  • Bioimaging

Current Appointments:

Vice-Dean (Graduate Studies)
Head, Department of Microbiology & Immunology

Brief Description of Research:

Kevin SW TAN is Associate Professor at and Head of the Department of Microbiology and Immunology, National University of Singapore. He is also Vice-Dean, Graduate Studies, at the Yong Loo Lin School of Medicine and Head, Innovation in Graduate Studies, at the National University Health System. His curiosity for parasites originated from his graduate student days at NUS and blossomed during his postdoctoral stint at The Rockefeller University, New York City. He is relieved to be awarded tenure in 2011, and can now spend more time on social issues, such as public science education. Kevin’s research focuses on understanding how parasites commit suicide and exploiting such knowledge to trigger death mechanisms as an anti-parasite strategy. He is also interested in the problem of drug resistance and his team has recently come up with new ways to find drugs that overcome resistance. More recently, his team has embarked on projects focusing on the role of single cell eukaryotes (SCEs) in the host microbiome. He hopes that the research from his team would accelerate the finding of new cures for parasitic diseases.

Total Number of Publications:

Five Representative Publications:

1. Yason JA, Liang YR, Png CW, Zhang YL, Tan KSW (2019) Interactions between a pathogenic Blastocystis subtype and gut microbiota: in vitro and in vivo studies. Microbiome 7:30.
2. Li FJ, Tsaousis AD, Purton P, Chow VTK, He CY, Tan KSW (2019) Successful genetic transfection of the colonic parasite Blastocystis for reliable expression of ectopic genes. Sci. Rep. 9, 3159.
3. Tong JX, Ang SEL, Tan EHN, Tan KSW (2019) Viability screen of LOPAC1280 reveals tyrosine kinase inhibitor tyrphostin A9 as a novel partner drug for artesunate combinations to target the Plasmodium falciparum ring stage. Antimicrob. Agents Chemother. 63(4):e02389-18.
4. Yason JA, Ajjampur SS, Tan KSW (2016) Blastocystis isolate B exhibits multiple modes of resistance against antimicrobial peptide LL-37. Infect. Immun. 84(8):2220-2232.
5. Wang JG, Zhang CJ, Chia WN, Loh CCY, Li ZJ, Lee YM, He YK, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang JB, Lu NC, Lim CT, Hua ZC, Liu B, Shen HM, Tan KSW,* Lin QS* (2015) Heme-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat. Commun. 6:10111 (* co-corresponding authors)

My Research Videos:

Top 5 Publications:

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Journals Published:

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Shyong Wei, Kevin Tan

Associate Professor
Medicine (Microbiology & Immunology)

Appointments

Vice-Dean (Graduate Studies)
Head, Department of Microbiology & Immunology

Education

National University of Singapore
Singapore

Research Areas

  • Malaria
  • Cell Death
  • Blastocystis
  • Microbiome
  • Bioimaging

Research Description

Kevin SW TAN is Associate Professor at and Head of the Department of Microbiology and Immunology, National University of Singapore. He is also Vice-Dean, Graduate Studies, at the Yong Loo Lin School of Medicine and Head, Innovation in Graduate Studies, at the National University Health System. His curiosity for parasites originated from his graduate student days at NUS and blossomed during his postdoctoral stint at The Rockefeller University, New York City. He is relieved to be awarded tenure in 2011, and can now spend more time on social issues, such as public science education. Kevin’s research focuses on understanding how parasites commit suicide and exploiting such knowledge to trigger death mechanisms as an anti-parasite strategy. He is also interested in the problem of drug resistance and his team has recently come up with new ways to find drugs that overcome resistance. More recently, his team has embarked on projects focusing on the role of single cell eukaryotes (SCEs) in the host microbiome. He hopes that the research from his team would accelerate the finding of new cures for parasitic diseases.

Research Videos

Selected Publications

(out of publications)

1. Yason JA, Liang YR, Png CW, Zhang YL, Tan KSW (2019) Interactions between a pathogenic Blastocystis subtype and gut microbiota: in vitro and in vivo studies. Microbiome 7:30.
2. Li FJ, Tsaousis AD, Purton P, Chow VTK, He CY, Tan KSW (2019) Successful genetic transfection of the colonic parasite Blastocystis for reliable expression of ectopic genes. Sci. Rep. 9, 3159.
3. Tong JX, Ang SEL, Tan EHN, Tan KSW (2019) Viability screen of LOPAC1280 reveals tyrosine kinase inhibitor tyrphostin A9 as a novel partner drug for artesunate combinations to target the Plasmodium falciparum ring stage. Antimicrob. Agents Chemother. 63(4):e02389-18.
4. Yason JA, Ajjampur SS, Tan KSW (2016) Blastocystis isolate B exhibits multiple modes of resistance against antimicrobial peptide LL-37. Infect. Immun. 84(8):2220-2232.
5. Wang JG, Zhang CJ, Chia WN, Loh CCY, Li ZJ, Lee YM, He YK, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang JB, Lu NC, Lim CT, Hua ZC, Liu B, Shen HM, Tan KSW,* Lin QS* (2015) Heme-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat. Commun. 6:10111 (* co-corresponding authors)