Jinhua Lu

Singapore
Associate Professor

Postgraduate:

University of Oxford
United Kingdom

Main Appointment:

Medicine (Microbiology & Immunology)

Joint Appointments:

Joint Appointments:
  • Institute of Molecular & Cell Biology (IMCB)
  • Research Fields:

    [supervisor_research_field]

    Research Areas:

    [supervisor_research_area]

    Research Fields:

    • STEMM – Science, Technology, Engineering, Mathematics, Medical Sciences

    Research Keywords:

    • Recombinant Vaccine
    • Adjuvant
    • Cancer
    • Viral
    • Translational

    Current Appointments:

    Resident Advisor, PGPR, Office Of Student Affairs

    Brief Description of Research:

    Since 2019, we have embarked on a translation project to develop a new adjuvant platform for therapeutic cancer and viral vaccines. The adjuvant platform has been filed for patents and this project has gained supports from three technology acceleration agencies. Basically, our invention is a panel of adjuvants that overcome the barrier that current recombinant vaccines encounter, i.e. the failure to induce cytotoxic T lymphocyte immunity which is key to cancer cell killing and eradication of chronic viral infections. The platform consists of three components: 1) the generation of vaccine antigens using eukaryotic, yeast, bacterial and synthesis methods; 2) immunological assays to evaluate responses to vaccines in vivo and ex vivo; and 3) disease models for preclinical efficacy/toxicity studies preparing for clinical trials. A PhD project is available that involves mainly the 1st and 2nd segments.

    Total Number of Publications:

    78

    Five Representative Publications:

    1. Cai Y, Teo BH, Yeo JG and Lu J. 2015. C1q binds to apoptotic nucleolus and causes C1 protease degradation of nucleolar proteins. J. Biol. Chem. 290, 22570.
    2. Yeo JG, Leong J, Arkachaisri T, Cai Y, Teo BH, Tan JH, Das L and Lu J. 2016. Proteolytic
    inactivation of nuclear alarmin high-mobility group box 1 by complement protease C1s during
    apoptosis. Cell Death Discov. 2,16069.
    3. Lu J and Kishore U. 2017. C1 Complex: An Adaptable Proteolytic module for complement and
    non-complement functions. Front Immunol. 8, 592.
    4. Cai Y, Wee SY, Chen J, Teo BH, Ng YL, Leong KP, and Lu J. 2018. Broad susceptibility of
    nucleolar proteins and autoantigens to complement C1 protease degradation. J Immunol.
    199, 3981
    5. Chen J, Teo BHD, Cai Y, Wee SY, Lu J. 2018. The linker histone H1.2 is a novel component of
    the nucleolar organizer regions. J Biol Chem. 193, 2358

    My Research Videos:

    Top 5 Publications:

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    Journals Published:

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    Jinhua Lu

    Associate Professor
    Medicine (Microbiology & Immunology)
    Institute of Molecular & Cell Biology (IMCB)

    Appointments

    Resident Advisor, PGPR, Office Of Student Affairs

    Education

    University of Oxford
    United Kingdom

    Research Areas

    • Recombinant Vaccine
    • Adjuvant
    • Cancer
    • Viral
    • Translational

    Research Description

    Since 2019, we have embarked on a translation project to develop a new adjuvant platform for therapeutic cancer and viral vaccines. The adjuvant platform has been filed for patents and this project has gained supports from three technology acceleration agencies. Basically, our invention is a panel of adjuvants that overcome the barrier that current recombinant vaccines encounter, i.e. the failure to induce cytotoxic T lymphocyte immunity which is key to cancer cell killing and eradication of chronic viral infections. The platform consists of three components: 1) the generation of vaccine antigens using eukaryotic, yeast, bacterial and synthesis methods; 2) immunological assays to evaluate responses to vaccines in vivo and ex vivo; and 3) disease models for preclinical efficacy/toxicity studies preparing for clinical trials. A PhD project is available that involves mainly the 1st and 2nd segments.

    Research Videos

    Selected Publications

    (out of 78 publications)

    1. Cai Y, Teo BH, Yeo JG and Lu J. 2015. C1q binds to apoptotic nucleolus and causes C1 protease degradation of nucleolar proteins. J. Biol. Chem. 290, 22570.
    2. Yeo JG, Leong J, Arkachaisri T, Cai Y, Teo BH, Tan JH, Das L and Lu J. 2016. Proteolytic
    inactivation of nuclear alarmin high-mobility group box 1 by complement protease C1s during
    apoptosis. Cell Death Discov. 2,16069.
    3. Lu J and Kishore U. 2017. C1 Complex: An Adaptable Proteolytic module for complement and
    non-complement functions. Front Immunol. 8, 592.
    4. Cai Y, Wee SY, Chen J, Teo BH, Ng YL, Leong KP, and Lu J. 2018. Broad susceptibility of
    nucleolar proteins and autoantigens to complement C1 protease degradation. J Immunol.
    199, 3981
    5. Chen J, Teo BHD, Cai Y, Wee SY, Lu J. 2018. The linker histone H1.2 is a novel component of
    the nucleolar organizer regions. J Biol Chem. 193, 2358