John Yu-Shen Chen
Postgraduate:
Main Appointment:
Joint Appointments:
Research Fields:
Research Areas:
Research Fields:
- STEMM – Science, Technology, Engineering, Mathematics, Medical Sciences
Research Keywords:
- Staphylococcus
- Aureus
- Phage
- Pathogenicity
- Transduction
Current Appointments:
Brief Description of Research:
Research in the Chen lab focuses on the bacteriophages and pathogenicity islands of the bacterial pathogen Staphylococcus aureus. Recently, we have identified and characterized several novel and powerful mechanisms of gene transfer that are proposed to be the major means by which S. aureus evolves and acquires the antibiotic resistance and virulence factors that accelerate the emergence of new and progressively more pathogenic strains.
Total Number of Publications:
Five Representative Publications:
1. Genetic transduction by phages and chromosomal islands: The new and noncanonical. Chiang YN, Penadés JR, Chen J. PLoS Pathog. 2019 Aug 8;15(8):e1007878.
2. Hijacking the Hijackers: Escherichia coli Pathogenicity Islands Redirect Helper Phage Packaging for Their Own Benefit. Fillol-Salom A, Bacarizo J, Alqasmi M, Ciges-Tomas JR, Martínez-Rubio R, Roszak AW, Cogdell RJ, Chen J, Marina A, Penadés JR. Mol Cell. 2019 Jul 8. pii: S1097-2765(19)30473-3.
3. Genome hypermobility by lateral transduction. Chen J, Quiles-Puchalt N, Chiang YN, Bacigalupe R, Fillol-Salom A, Chee MSJ, Fitzgerald JR, Penadés JR. Science.2018 Oct 12;362(6411):207-212
4. Intra- and inter-generic transfer of pathogenicity island-encoded virulence genes by cos phages. Chen J, Carpena N, Quiles-Puchalt N, Ram G, Novick RP, Penadés JR.
ISME J. 2015 May; 9(5):1260-3
5. Pathogenicity island-directed transfer of unlinked chromosomal virulence genes. Chen J, Ram G, Penadés JR, Brown S, Novick RP. Mol Cell. 2015 Jan 8;57(1):138-49.
My Research Videos:
Top 5 Publications:
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Journals Published:
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Appointments
Education
Research Areas
- Staphylococcus
- Aureus
- Phage
- Pathogenicity
- Transduction
Research Description
Research in the Chen lab focuses on the bacteriophages and pathogenicity islands of the bacterial pathogen Staphylococcus aureus. Recently, we have identified and characterized several novel and powerful mechanisms of gene transfer that are proposed to be the major means by which S. aureus evolves and acquires the antibiotic resistance and virulence factors that accelerate the emergence of new and progressively more pathogenic strains.
Research Videos
Selected Publications
1. Genetic transduction by phages and chromosomal islands: The new and noncanonical. Chiang YN, Penadés JR, Chen J. PLoS Pathog. 2019 Aug 8;15(8):e1007878.
2. Hijacking the Hijackers: Escherichia coli Pathogenicity Islands Redirect Helper Phage Packaging for Their Own Benefit. Fillol-Salom A, Bacarizo J, Alqasmi M, Ciges-Tomas JR, Martínez-Rubio R, Roszak AW, Cogdell RJ, Chen J, Marina A, Penadés JR. Mol Cell. 2019 Jul 8. pii: S1097-2765(19)30473-3.
3. Genome hypermobility by lateral transduction. Chen J, Quiles-Puchalt N, Chiang YN, Bacigalupe R, Fillol-Salom A, Chee MSJ, Fitzgerald JR, Penadés JR. Science.2018 Oct 12;362(6411):207-212
4. Intra- and inter-generic transfer of pathogenicity island-encoded virulence genes by cos phages. Chen J, Carpena N, Quiles-Puchalt N, Ram G, Novick RP, Penadés JR.
ISME J. 2015 May; 9(5):1260-3
5. Pathogenicity island-directed transfer of unlinked chromosomal virulence genes. Chen J, Ram G, Penadés JR, Brown S, Novick RP. Mol Cell. 2015 Jan 8;57(1):138-49.