We are working to integrate modern sequencing and computational methods into the daily discovery process of microbiologists. Research in the lab builds on three major areas, covering in vivo disease models, in vitro manipulation of bacteria, and in silico analysis of experimental and sequencing data. Experimentally, we work on two main systems: urinary tract infections caused by Escherichia coli and invasive foodborne infections caused by Streptococcus agalactiae (Group B Streptococcus). We also have some explicitly computational projects which are exploring how bacteria, and their ability to cause disease, evolve. We also have interests in the spread of antibiotic resistance genes and synthetic biology.