Jun Siong Low
Postgraduate:
Main Appointment:
Joint Appointments:
Research Fields:
Research Areas:
Research Fields:
- STEMM – Science, Technology, Engineering, Mathematics, Medical Sciences
Research Keywords:
- Cancer Immunology
- T Cells
- B Cells
- Adaptive Immunity
- Immunotherapy
Current Appointments:
Brief Description of Research:
T and B cells are components of the immune system that are essential in fighting against infection-causing “foreign” pathogens, but are also involved in disease settings like cancer and autoimmunity where they can attack “self”. Our lab aims to understand the complex biology of T and B cells at the interplay of infection and cancer, by focusing on their phenotypic and functional profiles, antigen specificities and receptor repertoires. Our long-term goal is to develop rational and effective immune-based therapies to leverage on the immune system to fight cancer.
Total Number of Publications:
Five Representative Publications:
Low JS*, Jerak J*, Tortorici MA*, McCallum M, Pinto D, Cassotta A, Foglierini M, Mele F, Abdelnabi R, Weynand B, Noack J, Montiel-Ruiz M, Bianchi S, Benigni F, Sprugasci N, Joshi A, Bowen JE, Walls, AC, Jarrossay D, Morone D, Paparoditis P, Garzoni C, Ferrari P, Ceschi A, Neyts J, Purcell LA, Snell G, Corti D, Lanzavecchia A, Veesler D and Sallusto F. ACE2 engagement exposes the SARS-CoV-2 fusion peptide to broadly neutralizing antibodies. Science, 377 (2022). PMID: 35857703
Low JS*, Vaqueirinho D*, Mele F*, Foglierini M, Perotti M, Jarrossay D, Jovic S, Terrot T, Pellanda AF, Biggiogero M, Garzoni C, Ferrari P, Ceschi A, Lanzavecchia A, Cassotta A, Sallusto F. Clonal dissection of immunodominance and cross-reactivity of the CD4+ T cell response to SARS-CoV-2. Science, 372 (2021). PMID: 34006597
Low JS, Farsakoglu Y, Amezcua Vesely MC, Sefik E, Kelly JB, Harman CCD, Jackson R, Shyer JA, Jiang X, Cauley LS, Flavell RA, Kaech SM. Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses. Journal of Experimental Medicine, 217 (2020). Cover story. PMID: 32525985
Pinto D*, Sauer MM*, Czudnochowski N*, Low JS*, Tortorici MA, Housley MP, Noack J, Walls AC, Bowen JE, Guarino B, Rosen LE, Iulio J, Jerak J, Kaiser H, Islam S, Jaconi S, Sprugasci N, Culap K, Abdelnabi R, Foo C, Coelmont L, Bartha I, Bianchi S, Silacci-Fregni C, Bassi J, Marzi R, Vetti E, Cassotta A, Ceschi A, Ferrari P, Cippà PE, Giannini O, Ceruti S, Garzoni C, Riva A, Benigni F, Cameroni E, Piccoli L, Pizzuto MS, Smithey M, Hong D, Telenti A, Lempp FA, Neyts J, Havenar-Daughton C, Lanzavecchia A, Sallusto F, Snell G, Virgin HW, Beltramello M, Corti D, Veesler D. Broad betacoronavirus neutralization by a stem helix–specific human antibody. Science, 373 (2021). PMID: 34344823
My Research Videos:
Top 5 Publications:
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Journals Published:
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Appointments
Education
Research Areas
- Cancer Immunology
- T Cells
- B Cells
- Adaptive Immunity
- Immunotherapy
Research Description
T and B cells are components of the immune system that are essential in fighting against infection-causing “foreign” pathogens, but are also involved in disease settings like cancer and autoimmunity where they can attack “self”. Our lab aims to understand the complex biology of T and B cells at the interplay of infection and cancer, by focusing on their phenotypic and functional profiles, antigen specificities and receptor repertoires. Our long-term goal is to develop rational and effective immune-based therapies to leverage on the immune system to fight cancer.
Research Videos
Selected Publications
Low JS*, Jerak J*, Tortorici MA*, McCallum M, Pinto D, Cassotta A, Foglierini M, Mele F, Abdelnabi R, Weynand B, Noack J, Montiel-Ruiz M, Bianchi S, Benigni F, Sprugasci N, Joshi A, Bowen JE, Walls, AC, Jarrossay D, Morone D, Paparoditis P, Garzoni C, Ferrari P, Ceschi A, Neyts J, Purcell LA, Snell G, Corti D, Lanzavecchia A, Veesler D and Sallusto F. ACE2 engagement exposes the SARS-CoV-2 fusion peptide to broadly neutralizing antibodies. Science, 377 (2022). PMID: 35857703
Low JS*, Vaqueirinho D*, Mele F*, Foglierini M, Perotti M, Jarrossay D, Jovic S, Terrot T, Pellanda AF, Biggiogero M, Garzoni C, Ferrari P, Ceschi A, Lanzavecchia A, Cassotta A, Sallusto F. Clonal dissection of immunodominance and cross-reactivity of the CD4+ T cell response to SARS-CoV-2. Science, 372 (2021). PMID: 34006597
Low JS, Farsakoglu Y, Amezcua Vesely MC, Sefik E, Kelly JB, Harman CCD, Jackson R, Shyer JA, Jiang X, Cauley LS, Flavell RA, Kaech SM. Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses. Journal of Experimental Medicine, 217 (2020). Cover story. PMID: 32525985
Pinto D*, Sauer MM*, Czudnochowski N*, Low JS*, Tortorici MA, Housley MP, Noack J, Walls AC, Bowen JE, Guarino B, Rosen LE, Iulio J, Jerak J, Kaiser H, Islam S, Jaconi S, Sprugasci N, Culap K, Abdelnabi R, Foo C, Coelmont L, Bartha I, Bianchi S, Silacci-Fregni C, Bassi J, Marzi R, Vetti E, Cassotta A, Ceschi A, Ferrari P, Cippà PE, Giannini O, Ceruti S, Garzoni C, Riva A, Benigni F, Cameroni E, Piccoli L, Pizzuto MS, Smithey M, Hong D, Telenti A, Lempp FA, Neyts J, Havenar-Daughton C, Lanzavecchia A, Sallusto F, Snell G, Virgin HW, Beltramello M, Corti D, Veesler D. Broad betacoronavirus neutralization by a stem helix–specific human antibody. Science, 373 (2021). PMID: 34344823