Vincenzo Sorrentino

Research Interest

Biology of aging with a focus on the interconnection between mitochondrial homeostasis and proteostasis.

Current Research Projects

The projects explore the interconnectivity and possible therapeutic targeting of the cellular hallmarks of the aging process, with a particular focus on mitochondrial dysfunction, protein aggregation and alterations of NAD+ metabolism. Dr. Vincenzo Sorrentino’s recent work was pivotal in establishing a functional and druggable interdependence between mitochondrial stress response pathways, NAD+ boosting and amyloid aggregation in Alzheimer’s disease (Nature, 2017 DOI: 10.1038/nature25143) and muscle aging (Cell Reports 2021, DOI: 10.1016/j.celrep.2020.108660). Several projects are currently open in the Sorrentino’s laboratory:

1. Characterization of a novel NAD+ precursor for muscle and brain health in aging
2. Dissecting cellular pathways of aging- and senescence-associated amyloidosis
3. Elucidation of common proteotoxic stress response signatures across aging and age-related diseases

PI’s laboratory focuses on:

1. Biology of aging
2. Proteostasis
3. Mitochondria and NAD+ metabolism
4. Preclinical models of neuromuscular disease (e.g. C. elegans, cell lines, rodents)