Siew Cheng Phua
Postgraduate:
Main Appointment:
Joint Appointments:
Research Fields:
Research Areas:
Research Fields:
- STEMM – Science, Technology, Engineering, Mathematics, Medical Sciences
Research Keywords:
- Neuroscience
- Circadian Rhythm And Disorders
- In Vivo Neuronal Imaging
- Proteomics
- Molecular And Cell Signaling
Current Appointments:
Brief Description of Research:
The Multiscale Neurobiology Lab is established in CBIS since January 2022- we are combining molecular techniques with in vivo imaging and behavior approaches to illuminate the cell biology that goes on inside the mammalian brain and the implications on behavior. Currently, a range of projects are being developed to investigate circadian signaling mechanisms in the brain that regulate our fundamental behaviors such as sleep, feeding and locomotion. Our long-term goal is to understand the molecular basis of what a "behavioral state" is and to harness these knowledge to develop strategies to treat circadian-related disorders e.g. Parkinson's.
Total Number of Publications:
Five Representative Publications:
Phua, S.C.#, Tan, Y.L.#, Kok, A.M.Y., Senol, E., Chiam, C.J.H., Lee, C.Y., Peng, Y., Lim, A.T.J., Mohammad, H., Lim, J.X., Fu, Y#. A distinct parabrachial to lateral hypothalamus circuit for motivational suppression of feeding by nociception. Science Advances 2021; 7(19), eabe4323. (#co-correspondence)
Jia, S., Phua, S.C., Nihongaki, Y., Li, Y., Pacella, M., Li, Y., Mohammad, A.M., Sun, S., Inoue, T., Schulman, R. Growth and site-specific organization of micron-scale biomolecular devices on living mammalian cells. Nature Communications 2021; 12(5279).
Phua S.C.#, Chiba S., Suzuki M., Su E., Roberson E.C., Pusapati G.V., Setou M., Rohatgi R., Reiter J.F., Ikegami K.#, Inoue T.# Dynamic remodeling of membrane composition drives cell cycle through primary cilia excision. Cell 2017; 168(1-2), 264-279. (#co-correspondence)
Garcia-Gonzalo F.R.*, Phua S.C.*, Roberson E.C., Garcia III G., Abedin M., Schurmans S., Inoue T., Reiter J.F. Ciliary phosphoinositides modulate Hedgehog signaling. Developmental Cell 2015; 34(4), 400-409. (*co-first)
Su S.*, Phua S.C.*, DeRose R., Chiba S., Narita K., Kalugin P.N., Katada T., Kontani K., Takeda S., and Inoue T. Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia. Nature Methods 2013; 10(11), 1105-1107. (*co-first)
Phua S.C., Pohlmeyer C., Inoue T. Rapidly relocating molecules between organelles to manipulate small GTPase activity. ACS Chemical Biology 2012; 7(12): 1950-1955.
My Research Videos:
Top 5 Publications:
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Journals Published:
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Appointments
Education
Research Areas
- Neuroscience
- Circadian Rhythm And Disorders
- In Vivo Neuronal Imaging
- Proteomics
- Molecular And Cell Signaling
Research Description
The Multiscale Neurobiology Lab is established in CBIS since January 2022- we are combining molecular techniques with in vivo imaging and behavior approaches to illuminate the cell biology that goes on inside the mammalian brain and the implications on behavior. Currently, a range of projects are being developed to investigate circadian signaling mechanisms in the brain that regulate our fundamental behaviors such as sleep, feeding and locomotion. Our long-term goal is to understand the molecular basis of what a "behavioral state" is and to harness these knowledge to develop strategies to treat circadian-related disorders e.g. Parkinson's.
Research Videos
Selected Publications
Phua, S.C.#, Tan, Y.L.#, Kok, A.M.Y., Senol, E., Chiam, C.J.H., Lee, C.Y., Peng, Y., Lim, A.T.J., Mohammad, H., Lim, J.X., Fu, Y#. A distinct parabrachial to lateral hypothalamus circuit for motivational suppression of feeding by nociception. Science Advances 2021; 7(19), eabe4323. (#co-correspondence)
Jia, S., Phua, S.C., Nihongaki, Y., Li, Y., Pacella, M., Li, Y., Mohammad, A.M., Sun, S., Inoue, T., Schulman, R. Growth and site-specific organization of micron-scale biomolecular devices on living mammalian cells. Nature Communications 2021; 12(5279).
Phua S.C.#, Chiba S., Suzuki M., Su E., Roberson E.C., Pusapati G.V., Setou M., Rohatgi R., Reiter J.F., Ikegami K.#, Inoue T.# Dynamic remodeling of membrane composition drives cell cycle through primary cilia excision. Cell 2017; 168(1-2), 264-279. (#co-correspondence)
Garcia-Gonzalo F.R.*, Phua S.C.*, Roberson E.C., Garcia III G., Abedin M., Schurmans S., Inoue T., Reiter J.F. Ciliary phosphoinositides modulate Hedgehog signaling. Developmental Cell 2015; 34(4), 400-409. (*co-first)
Su S.*, Phua S.C.*, DeRose R., Chiba S., Narita K., Kalugin P.N., Katada T., Kontani K., Takeda S., and Inoue T. Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia. Nature Methods 2013; 10(11), 1105-1107. (*co-first)
Phua S.C., Pohlmeyer C., Inoue T. Rapidly relocating molecules between organelles to manipulate small GTPase activity. ACS Chemical Biology 2012; 7(12): 1950-1955.